The pupillary effects of retrobulbar injection of botulinum toxin A (oculinum) in albino rats.

نویسندگان

  • Y Levy
  • I Kremer
  • S Shavit
  • A D Korczyn
چکیده

Botulinum toxin (BoTx) has been clinically used in the treatment of localized dystonic states such as blepharospasm, as well as in strabismus. Reported side effects have included primary excessive weakness of neighboring extraocular muscles. To evaluate possible involvement of the iris, we injected BoTx into the retrobular space of albino rats. Ipsilateral mydriasis with cholinomimetic supersensitivity developed in the treated animals. There was no apparent optic nerve dysfunction. The authors observed these effects using BoTx doses insufficient to cause clinical weakness or electrophysiological evidence of generalized neuromuscular dysfunction. The mydriasis disappeared spontaneously within 2-3 weeks. Higher BoTx doses resulted in severe neuromuscular paralysis and death. These findings were consistent with clinical botulism, which may include autonomic paralysis. The site of BoTx action could be the ciliary ganglion or cholinergic terminals in the iris. The authors concluded that side effects of BoTx were not necessarily limited to striated muscle weakness.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of effect of botulinum toxin with clopidogrel and concomitant prescription of them in the survival of random skin flap in rats

Introduction: In this study, the effect of botulinum toxin A and clopidogrel and concomitant administration of them in the survival of random skin flap in rat model were studied. Correspondence: Ghasemali. Khorasani, MD. Surgery Department, Immam Khomeini Hospital Complex, Tehran University of Medical Sciences. ...

متن کامل

Histopathologic Changes of Extraocular Mus-cle Fibers after Injection of Botulinum Toxin

Background: Use of botulinum toxin is becoming a popular way in treatment of some forms of strabismus.To evaluate the morphological changes in the orbital surface layer muscles of the rabbit eye following a single injection of botulinum toxin. Methods: 10 white Dutch rabbits weighing 2–3 kg received either 10 units (group 1; n=5) or 20 units (group 2; n=5) of botulinum toxin into the superior r...

متن کامل

Combined effect of botulinum toxin and splinting on motor components and function of people suffering a stroke

Background: Spasticity is one of the problems after a stroke. Due to this increase in muscle tone, patients are confronted with problems in motor control and difficulties in activities of daily living and complications such as shortness and contracture. The aim of this study was to examine the effects of the simultaneous use of both splint and botulinum toxin-A (BTX-A) injection on spasticity, ...

متن کامل

Botulinum Toxin Injections or Application of Splints: Impact on Spasticity, Range of Motion and Function of Upper Extremity in Chronic Stroke Patients

Spasticity or increase in muscle tone is one of the problems following stroke. Due to this increase in muscle tone, patients are confronted to problems in motor control and difficulties in activities of daily living and complications such as shortness and contracture. The aim of this study is to compare the effects of using splint or botulinum toxin injection on spasticity, range of motion and ...

متن کامل

Treatment of severe axillary Hyperhidrosis with Botulinum toxin A

Background: Severe axillary hyperhidrosis causes considerable emotional stress to individuals affected with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity and sequelae. Objective: In this study we attempted to determine the effect of botulinum toxin A (Dysport) in the treatment of axillary hyperhidrosis. Patients and Meth...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Investigative ophthalmology & visual science

دوره 32 1  شماره 

صفحات  -

تاریخ انتشار 1991